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Zolendronic Acid, Zometa, Bisophonates


I wanted to ask about Zolendronic Acid, Ihave recently had my 3rd Bisophante injection. It had been postponed due to the Covid Pandemic, my Oncologist informed me that this wouldn't matter too much. I also had a bone scan which shows no abnormalities, so I am happy to continue with the bi annual infusion. My questions are these:-

Why do some patients have Demonusub rather than Zolendronic Acid?

Does anyone know the reason some patients should NOT take ibuprofen after the infusion?

Is there an advantage in having this infusion over a long period of time rather than a fast injection.

What is the optimal dose

Has anyone felt the dreadful after effects of whole body aches, or any other S.E's

I would be grateful for any tips, advice etc.. I am being given conflicting advice from my health care professionals.


  • LouiseJLouiseJ Posts: 850 ✭✭✭✭✭

    @PAwsnjaws @LizzyB73


    Welcome to the community,

    I have tagged Liz in this chat, Liz is one of our experts here, she is a Oncology Specialist Nurse here in the UK, and may be able to answer your questions with far more knowledge and insight than I know I ever could!

    I expect there are others here too who have had similar treatments as yourself with some of the drugs used.

    I hope they will get in touch soon,

    I had heard that some treatments had been postponed due to the Covid situation, I hope that your treatment will now presume and continue without further delays.

    Lou x

  • LizzyB73LizzyB73 Posts: 112 Oncology Specialist Nurse

    HI @PAwsnjaws

    Thanks for getting in touch with regards to the differences between denosumab and zometa

    There has been a study which showed that denosumab faired slightly better at reducing risk of bone problems for women with breast cancer that had already spread but that the side effect profile of flu like symptoms was fairly similar.

    I attach details of both the drugs which may be useful for you to read.

    wishing you all the best

    Liz 💕

    Liz Bradley
    Oncology Specialist Nurse | Oncology Service Manager @ Springfield Hospital
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